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News-Archive

Study site in 4 more countries open for recruitment

published: September 5th 2019

During the first half of 2019, study sites in Finland, Norway, Belgium and Italy have opened for patient recruitment. In total, ALBINO is now recruiting in 10 countries.

Recruitment now open in Estonia and Spain

published: March 14th 2019

The ALBINO-consortium happily announces the official opening of the first centers for patient recruitment in Estonia and Spain.

Recruitment open and first patient included in Austria

published: November 28th 2018

Recruitment for the ALBINO-study was successfully opened in Austria, and the first patient has been enrolled already.

First Patients Included

published: July 10th 2018

Since the opening of the first study sites in the Netherlands and Germany, 4 patients have been successfully included into the ALBINO-trial (2 in the Netherlands, 2 in Germany).

Recruitment now open in Switzerland

published: July 10th 2018
The ALBINO-consortium happily announces the official opening of two centres for patient recruitment in Switzerland.

Recruitment now open in the Netherlands and Germany

published: June 6th 2018

The ALBINO-consortium happily announces the official opening of several centres for patient recruitment in the Netherlands and Germany. We are confident that more countries will follow soon.

Approvals received in Portugal

published: November 21st 2019

On 08 November, 2019 partner UPORTO received all necessary approvals to start patient recruitment for the ALBINO-trial in Portugal. Portugal is now the 11th country recruiting for ALBINO.

Events

Past Events

ALBINO Investigator Meeting at GNPI 2020, June 18th 2020

The ALBINO-trial will be present at the 46th Annual Conference of the German Society for Neonatology and Paediatric Intensive Care (GNPI) in Berlin, Germany, Estrel-Hotel and Congress Center, from June 18-20, 2020.
Further information is available at gnpi2020.de.

ALBINO-investigators from Germany, Austria and Switzerland will convene room NIZZA on Friday, 18 June, 2020, 11.15-12.15 am. All participating investigators and interested new investigators are cordially invited to join and learn about the latest news and conditions for trial participation.

ALBINO Presentation at the 11th Dresden Symposium on Delivery Room Management and Regenerative Therapies, March 5th 2020

The ALBINO-trial will be presented by Axel Franz in the session on Neonatal Brain Injury on Thursday, 05 March, 2020.
Further information is available at here

Next ALBINO General Assembly Meeting in Berlin, March 4th 2020

The members of the ALBINO-consortium will once again meet on 04 March, 2020 at Berlin, Tegel Airport.

ALBINO Investigator Meeting in Germany, May 24th 2019

The next investigator meeting for participating and interested centers will take place at the annual GNPI congress 2019 in Leipzig. The meeting will be held on 24 May, 2019, 12-1pm.

ALBINO Consortium Meeting in Germany, April 10th 2019

The ALBINO consortium will convene in Frankfurt, Germany on 10 April, 2019 for its first consortium meeting in 2019.

ALBINO Investigator Meetings in Italy and Norway, June 11th 2018

In order to speed up the trial roll-out in further European countries, investigator meetings will be held in Italy and Norway. In Italy the meeting will take place at the Hotel Courtyard by Marriott in Tessera, Venice on 11 June, 2018, 11 am to 4 pm. In Norway, investigators will convene at Oslo University Hospital on 12 June, 2018, from 9 am until 4 pm.

ALBINO Investigator Meeting at GNPI 2018, June 9th 2018

The ALBINO-trial will be present at the 44th Annual Conference of the German Society for Neonatology and Paediatric Intensive Care (GNPI) in Rostock, Germany, from June 07-09, 2018. Further information is available at www.gnpi2018.de.

ALBINO-investigators from Germany, Austria and Switzerland will convene in Hall 8 on Saturday, 09 June, 2018, 12.45-1.45 pm. All participating investigators and interested new investigators are cordially invited to join and learn about the latest news and conditions for trial participation.

ALBINO presented at the “9th Dresden Symposium on Delivery Room Manage-ment, Asphyxia, Hypothermia and Stem cell research, March 9th 2018

The progress and state of affairs of the ALBINO-study will be presented at the “9th Dresden Symposium on Delivery Room Management, Asphyxia, Hypothermia and Stem cell re-search” which is held from 08-09 March, 2018 in Dresden, Germany. This symposium is a regular convention of national and international researchers and experts on hypothermia, and we hope for interesting inputs and discussions for various perspectives.

Annual ALBINO-Meeting to be held in Dresden, Germany, March 7th 2018

The ALBINO-consortium will hold its annual meeting in Dresden, Germany on 07 March, 2018. For the 2nd time, the annual spring meeting will be hosted by TUD and EKUT. We are looking forward to fruitful discussions among all partners.

Publication

Four peer reviewed papers on ALBINO Work Package 6 published

WP6 Lead Partner UMCU published four papers on MRI-analyses in the context of HIE-diagnosis in term born neonates in “Pediatric Research” and the “American Journal of Neuroradiology”:

Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility. Annink KV, van der Aa NE, Dudink J, Alderliesten T, Groenendaal F, Lequin M, Jansen FE, Rhebergen KS, Luijten P, Hendrikse J, Hoogduin HJM, Huijing ER, Versteeg E, Visser F, Raaijmakers AJE, Wiegers EC, Klomp DWJ, Wijnen JP, Benders MJNL. AJNR Am J Neuroradiol. 2020 Aug;41(8):1532-1537. doi: 10.3174/ajnr.A6702. Epub 2020 Jul 30.

The development and validation of a cerebral ultrasound scoring system for infants with hy-poxic-ischaemic encephalopathy. Annink KV, de Vries LS, Groenendaal F, Vijlbrief DC, Weeke LC, Roehr CC, Lequin M, Reiss I, Govaert P, Benders MJNL, Dudink J. Pediatr Res. 2020 Mar;87(Suppl 1):59-66. doi: 10.1038/s41390-020-0782-0.

Cerebellar injury in term neonates with hypoxic-ischemic encephalopathy is underestimated. Annink KV, Meerts L, van der Aa NE, Alderliesten T, Nikkels PGJ, Nijboer CHA, Groenen-daal F, de Vries LS, Benders MJNL, Hoebeek FE, Dudink J. Pediatr Res. 2020 Sep 23. doi: 10.1038/s41390-020-01173-z. Online ahead of print.

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia cal-culated using magnetic resonance spectroscopy. Annink KV, Groenendaal F, Cohen D, van der Aa NE, Alderliesten T, Dudink J, Benders MJNL, Wijnen JP. Pediatr Res. 2020 Aug; 88(2):279-284. doi: 10.1038/s41390-019-0739-3. Epub 2020 Jan 2.

First results from WP8 published in Clinical Pharmacokinetics

WP8 Academic Lead Partner KULEUVEN and the study group involved in WP 8 pub-lished important results on pharmacokinetics in the ALBINO trial:

Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypo-thermia, Quantified by Mannitol Clearance. Deferm N, Annink KV, Faelens R, Schroth M, Maiwald CA, Bakkali LE, van Bel F, Benders MJNL, van Weissenbruch MM, Hagen A, Smits A, Annaert P, Franz AR, Allegaert K; ALBI-NO Study Group. Clin Pharmacokinet. 2021 Feb 21. doi: 10.1007/s40262-021-00991-6. On-line ahead of print.

Second peer-reviewed publication on ALBINO now available in BMC Pediatrics

Maiwald et al.’s paper “Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo controlled parallel group multicenter trial for superiority (phase III)” is now available in BMC Pediatrics. Please visit https://rdcu.be/bH0i2 for open access to full text.

First peer-reviewed journal article on ALBINO has been published

Annink et al.’s review article “Allopurinol: Old Drug, New Indication in Neonates?“ is now available in Current Pharmaceutical Design, https://benthamscience.com/journals/current-pharmaceutical-design.